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CBD Distillate vs. Isolate

Updated: Oct 17


A cannabis leaf rests behind a tincture bottle filled with golden liquid

CBD distillate and isolate are two commonly used forms of cannabidiol, each offering unique characteristics that can influence product development and business strategies. For decision-makers in the cannabinoid industry, understanding how these two types differ is essential when choosing the right product for specific needs. 


Distillate retains a range of cannabinoids, while isolate provides pure CBD without additional compounds. This article will break down the core distinctions between the two, helping you assess which option is most suitable for your business goals and production requirements.


Key Takeaways


  • CBD distillate contains 80-90% CBD and retains other cannabinoids, offering a potent and versatile hemp extract for products.


  • CBD isolate is 99% pure CBD without additional cannabinoids or THC, ideal for precise dosing and THC-sensitive consumers.

  • Distillate offers the entourage effect, as it retains minor cannabinoids, while isolate lacks this synergy but ensures THC-free formulations.

  • CBD isolate is odorless, flavorless, and easier to incorporate into products like edibles, supplements, or cosmetics for precise formulations.

  • Choose CBD isolates for THC-free compliance or distillate for broader therapeutic benefits and customizable formulations with minor cannabinoids.

  • For high-quality CBD distillate and isolate, Arvida Labs provides rigorously tested, US-grown products produced in GMP-certified facilities.

What is CBD Distillate?

CBD distillate is a refined hemp extract that contains a high concentration of cannabidiol (CBD) and other cannabinoids, but it typically lacks terpenes, which are removed during the distillation process. 

Manufacturers sometimes add terpenes back into the distillate for flavor and aroma, but the base product itself is usually terpene-free. The distillation process purifies the extract by removing unwanted compounds like chlorophyll, waxes, and fats, resulting in a potent product that typically contains 80-90% CBD.


CBD distillate is commonly used in various cannabis products, such as tinctures, edibles, and topicals, for its potency and versatility.

Pros of CBD Distillate

Here are some reasons why CBD distillate should be on your shopping list the next time you’re browsing a cannabis store.

  • High Potency: CBD distillate typically contains 80-90% pure CBD, making it a highly concentrated form of cannabidiol. This allows manufacturers to create potent products without the need for excessive amounts of raw material.

  • Versatility: CBD distillate can be easily incorporated into various product formulations, including tinctures, edibles, vape cartridges, and topicals. Its odorless and flavorless nature, unless terpenes are added back, makes it adaptable to different applications.

  • Customizable Formulations: Manufacturers can add terpenes, flavorings, or other cannabinoids like CBG or CBN to create tailored products. This flexibility is especially beneficial for creating targeted formulations based on specific consumer needs.

  • Minimal THC Content: CBD distillate contains negligible amounts of THC (usually less than 0.3%), making it compliant with legal requirements in many regions while avoiding psychoactive effects.

  • Entourage Effect Potential: Although terpenes are removed during distillation, the distillate retains minor cannabinoids, which can contribute to enhanced therapeutic effects through the entourage effect when combined with other cannabis compounds.

Cons of CBD Distillate

While CBD distillate offers many benefits, it does have some drawbacks. Here’s what you need to know.

  • Loss of Terpenes: During the distillation process, terpenes are removed, which diminishes the natural flavor and aroma of the extract. While terpenes can be added back, the final product lacks the full, original profile of the hemp plant.

  • Limited Entourage Effect: Although CBD distillate retains some minor cannabinoids, it lacks the full range of compounds found in full-spectrum extracts. This can reduce the overall synergistic benefits of the entourage effect, which is achieved when all cannabinoids and terpenes work together.

  • Potential Trace Contaminants: Despite the refinement, trace amounts of unwanted compounds, such as pesticides or residual solvents, can sometimes remain if the distillation process is not properly managed or if the source material is of lower quality.

  • Drug Test Risk: Even though CBD distillate contains less than 0.3% THC, this trace amount can still accumulate in your system. Regular use of CBD distillate may result in a positive THC drug test, which can be a concern for individuals subject to routine testing.

What is CBD Isolate?

CBD isolate is the purest form of cannabidiol, consisting of 99% or more CBD without any other cannabinoids, terpenes, or plant compounds. It is typically found in crystalline powder form and is completely free of THC. 

To produce CBD isolate, manufacturers extract CBD from hemp and then refine it through multiple processes, removing all other components such as waxes, chlorophyll, and other cannabinoids. The result is a highly concentrated, odorless, and flavorless product.


CBD isolate is commonly used in products where precise dosing and THC-free formulations are critical, such as in pharmaceuticals, supplements, or cosmetics.

Benefits of CBD Isolate

CBD isolate is an attractive option for both manufacturers and consumers seeking the purest form of cannabidiol without additional plant compounds. Its simplicity and precision make it a valuable ingredient in the wellness, pharmaceutical, and cosmetic industries. The following are some specific benefits of CBD isolate:

  • Limited Risk of THC Contamination: Since it’s purely CBD, there is no possibility of THC contamination, which is critical for those in sensitive professions or areas with strict THC regulations. However, this does not mean that you’re 100% safe from drug tests. Depending on the manufacturer, the source of their cannabinoids, and the quality of their processes, you might still fail a drug test.

  • Extended Shelf Life: Without terpenes or other volatile compounds, CBD isolate tends to have a longer shelf life, making it more stable for long-term storage.

  • Custom Formulations: CBD isolate gives manufacturers more control, allowing them to create customized cannabinoid blends by adding specific cannabinoids or terpenes as needed.

  • Easier Compliance: With its THC-free composition, CBD isolate simplifies regulatory compliance, especially in regions with stringent rules on THC content in products.

Cons of CBD Isolate

While CBD isolate offers unique advantages, it's important to recognize that it may not be the perfect solution for every user or product. Like any other form of cannabidiol, CBD isolate has its limitations that can impact its effectiveness and suitability for specific applications. Here are some of the cons to consider:

  • Lack of Entourage Effect: CBD isolate doesn’t include the full spectrum of cannabinoids, terpenes, and other compounds found in hemp, which are believed to work synergistically to enhance therapeutic benefits. This means users miss out on the "entourage effect" that can increase efficacy.

  • Limited Therapeutic Range: Some users may find CBD isolate less effective for certain conditions compared to full-spectrum or broad-spectrum products, which offer a more diverse profile of active compounds.

  • Requires Careful Dosing: While precise dosing is a benefit, it also means that users must be extra careful to measure their intake properly, as the isolated form of CBD can make it easier to accidentally take too much or too little.

  • Flavorless and Odorless: Although often seen as an advantage, the lack of flavor or aroma can make CBD isolate less appealing in products where natural taste or fragrance are desired.

  • Less Bioavailable: Some believe that full-spectrum products may be more easily absorbed and used by the body, while isolated CBD may have slightly lower bioavailability.

How is CBD Distillate Made?

The production of CBD distillate involves several key steps, each crucial for creating a high-quality end product. Here’s an overview of the process.

1. Extraction

The process begins with extracting CBD from hemp plants. Manufacturers typically use solvents like CO2 or ethanol for this step. CO2 extraction is popular due to its efficiency and ability to produce a clean extract. Ethanol extraction, while more traditional, can also yield high-quality results when done properly.

2. Winterization

After extraction, the crude oil undergoes winterization. This step involves mixing the extract with ethanol and cooling it to subzero temperatures. The cold temperatures cause fats, waxes, and lipids to solidify, separating them from the desired cannabinoids.

3. Filtration

Once winterized, the mixture is filtered to remove the solidified plant matter and other unwanted compounds. This filtration process can involve multiple stages to ensure thorough purification of the extract.

4. Decarboxylation

The filtered extract then undergoes decarboxylation, a process that uses heat to activate the cannabinoids. This step converts CBDA (cannabidiolic acid) into CBD, making it more bioavailable and effective. The temperature and duration of this process are carefully controlled to maximize cannabinoid activation without degradation.

5. Distillation

The final step in creating CBD distillate is distillation. This process involves heating the decarboxylated extract to precise temperatures that cause the cannabinoids to vaporize.


These vapors are then cooled and condensed back into a liquid form, resulting in a highly concentrated CBD distillate. What is Cannabinoid Potency Testing explains how the final product is analyzed for quality and potency.


Throughout the production process, manufacturers must adhere to strict quality control standards. Novel food safety and CBD regulations have further emphasized the need for rigorous testing and safety measures in CBD distillate production.

How is CBD Isolate Produced from Distillate?

The production of CBD isolate from distillate is a multi-step process that focuses on purifying CBD to its most concentrated form. Below are the key stages involved in converting CBD distillate into CBD isolate:

1. Further Winterization

While distillate has already undergone winterization, small amounts of fats, waxes, and lipids may remain. Repeating this process guarantees that any residual impurities are completely removed, leaving a cleaner starting material for crystallization.

2. Decarboxylation Refinement

CBD distillate is often already decarboxylated, but ensuring complete conversion of CBDa (the acidic precursor to CBD) is crucial for producing isolate. Even a small amount of remaining CBDa could interfere with the crystallization process, so reheating ensures that all active CBD is present.

3. Crystallization

Once decarboxylation is complete, the purified CBD is dissolved in a solvent like pentane or heptane. This solution is then carefully cooled, prompting the formation of pure CBD crystals. These crystals are then filtered out of the solvent and further dried to remove any remaining solvent residues.

3. Additional Purification

Distillate may still contain trace cannabinoids, terpenes, and other compounds. For isolate production, any non-CBD components must be eliminated to ensure a pure, crystalline product.


Repeating the purification steps helps remove any remaining minor cannabinoids or terpenes, which are less of a concern in distillate but unacceptable in isolate production.

Through these processes, CBD distillate is converted into crystalline CBD isolate, offering the purest form of cannabidiol available.

Choosing Between CBD Isolate and Distillate


A cannabis leaf, some marijuana weeds, and a tincture of golden liquid are placed on a wooden surface

When deciding between CBD isolate and distillate, several factors can guide your choice based on your specific needs and goals. Understanding these factors can help you make an informed decision about which product is best for your business or personal use.

1. THC Sensitivity

If you’re concerned about even trace amounts of THC, whether for personal reasons or drug testing, CBD isolate is the clear choice. With 99% pure cannabidiol and zero THC, it’s ideal for those who need to avoid THC entirely.

2. Full-Range Benefits

If you're looking to benefit from the “entourage effect,” where cannabinoids and terpenes work synergistically, CBD distillate is a better fit. It retains minor cannabinoids like CBG or CBN, which can enhance the overall therapeutic experience.

3. Product Versatility

For manufacturers looking to create flavorless, odorless products, CBD isolate is the preferred option. Its neutral characteristics allow for greater flexibility when incorporating it into edibles, beverages, or cosmetics.

4. Precision Dosing

If precise dosing is critical, especially for medical formulations, CBD isolate offers more control. With pure CBD, you can measure exact milligrams without worrying about other cannabinoids altering the effect.

Ultimately, your decision depends on your specific needs, whether you’re seeking purity, enhanced therapeutic effects, or precise product formulation.

Closing Thoughts - What is the Most Effective Form of CBD?

In conclusion, determining the most effective form of CBD depends on your specific goals and needs.


CBD isolate offers pure cannabidiol without any other compounds, making it ideal for those avoiding THC or looking for precise dosing. On the other hand, CBD distillate retains other cannabinoids and can deliver the benefits of the "entourage effect."


The choice between the two is subjective, as what works best for one person might not be as effective for another. Ultimately, both forms are worth trying to see which delivers the desired results.

For those seeking high-quality CBD products, Arvida Labs is the best option for both distillate and isolate. We pride ourselves on providing pure, meticulously tested products produced in GMP-certified facilities.


Every product is accompanied by Certificates of Analysis (COAs), ensuring transparency and accountability. Whether you're a large manufacturer or a small-scale user, you can buy as much or as little as you need. Plus, we source all of our products from US-grown hemp, ensuring top-tier quality at every step.

Visit Arvida Labs today and browse through our collection of the purest CBD isolate and distillate available on the market!

Sources for this Article

  • jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-023-00186-9

  • mindfulmedicinal.com/how-to-use-cbd-distillate-products/

  • medicalnewstoday.com/articles/cbd-isolate

  • forbes.com/health/cbd/cbd-isolate/

  • ncbi.nlm.nih.gov/pmc/articles/PMC9504406/

  • brinstrument.com/blog/cannabis-distillation/winterization-of-cannabis-oil-extracts-to-remove-fats-and-waxes/

  • brinstrument.com/blog/cannabis-distillation/how-to-crystallize-cbd-make-cbd-isolate/

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